Migraine and Depression: Connecting the Dots
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Review Article
Migraine and Depression: Connecting the Dots
Zainab Samaan1 and Anne Farmer2
Affiliations: 1Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, ON, Canada and
2MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
ABSTRACT
Migraine and depression are common conditions that often coexist. The combination of several mechanisms may explain this comorbidity. A number of studies showed consistent association between depression and primary headache disorders including migraine; however, migraine with aura showed the strongest association with depression. This review highlights the background of migraine and depression, and summarizes studies that have investigated the risk for depression in migraine sufferers.
Keywords: migraine, depression, comorbidity, migraine with aura, genetics, MTHFR
Correspondence: Z Samaan, Department of Psychiatry and Behavioral Neurosciences, McMaster University, Mood Disorders Program, 100 West 5th Street, Hamilton, ON, Canada L8N 3K7. Tel: (1)‐905‐522‐1155, ext 36372; Fax: (1)‐905‐575‐6029; e‐mail: samaanz@mcmaster.ca
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